Distinct DNA Sequence Preference for Histone Occupancy in Primary and Transformed Cells
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چکیده
منابع مشابه
Predicting Human Nucleosome Occupancy from Primary Sequence
Nucleosomes are the fundamental repeating unit of chromatin and comprise the structural building blocks of the living eukaryotic genome. Micrococcal nuclease (MNase) has long been used to delineate nucleosomal organization. Microarray-based nucleosome mapping experiments in yeast chromatin have revealed regularly-spaced translational phasing of nucleosomes. These data have been used to train co...
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The DNTM3A and DNMT3B de novo DNA methyltransferases (DNMTs) are responsible for setting genomic DNA methylation patterns, a key layer of epigenetic information. Here, using an in vivo episomal methylation assay and extensive bisulfite methylation sequencing, we show that human DNMT3A and DNMT3B possess significant and distinct flanking sequence preferences for target CpG sites. Selection for h...
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ژورنال
عنوان ژورنال: Cancer Informatics
سال: 2019
ISSN: 1176-9351,1176-9351
DOI: 10.1177/1176935119843835